Weekend Box Office Results: George Clooney Has Moderate Opening, The Takers Holds Strong, but Machete is weak.
| 1 | N | The American | Focus | $12,968,000 | – | 2,823 | – | $4,594 | $16,114,000 | – | 1 | |
| 2 | 1 | Takers | SGem | $11,450,000 | -44.2% | 2,206 | – | $5,190 | $37,900,000 | $32 | 2 | |
| 3 | N | Machete | Fox | $11,300,000 | – | 2,670 | – | $4,232 | $11,300,000 | – | 1 | |
| 4 | 2 | The Last Exorcism | LGF | $7,645,000 | -62.5% | 2,874 | – | $2,660 | $32,477,000 | $1.8 | 2 | |
| 5 | N | Going the Distance | WB (NL) | $6,885,000 | – | 3,030 | – | $2,272 | $6,885,000 | – | 1 | |
| 6 | 3 | The Expendables | LGF | $6,592,000 | -30.8% | 3,398 | – | $1,940 | $92,159,000 | $80 | 4 | |
| 7 | 5 | The Other Guys | Sony | $5,400,000 | -14.1% | 2,607 | -574 | $2,071 | $106,866,000 | $100 | 5 | |
| 8 | 4 | Eat Pray Love | Sony | $4,850,000 | -28.8% | 2,663 | -445 | $1,821 | $68,954,000 | $60 | 4 | |
| 9 | 7 | Inception | WB | $4,530,000 | -7.1% | 1,704 | -366 | $2,658 | $277,103,000 | $160 | 8 | |
| 10 | 8 | Nanny McPhee Returns | Uni. | $3,575,000 | -24.2% | 2,708 | -90 | $1,320 | $22,441,000 | $35 | 3 | |
| 11 | 9 | The Switch | Mira. | $3,068,000 | -33.1% | 1,885 | -132 | $1,628 | $21,443,000 | – | 3 | |
| 12 | 6 | Vampires Suck | Fox | $3,000,000 | -42.5% | 2,434 | -799 | $1,233 | $32,298,000 | $20 | 3 | |
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| 13 | 13 | Despicable Me | Uni. | $2,824,000 | -1.2% | 1,587 | -246 | $1,779 | $240,275,000 | $69 | 9 | |
| 15 | 10 | Piranha 3D | W/Dim. | $2,300,000 | -46.5% | 1,789 | -702 | $1,286 | $22,396,000 | $24 | 3 | |
| 14 | 11 | Avatar: Special Edition | Fox | $2,300,000 | -42.6% | 812 | – | $2,833 | $7,820,000 | – | 2 | |
| 16 | 12 | Lottery Ticket | WB | $2,290,000 | -40.6% | 1,310 | -664 | $1,748 | $20,648,000 | $17 | 3 | |
| 17 | 19 | Toy Story 3 | BV | $1,900,000 | +88.0% | 1,520 | +920 | $1,250 | $408,055,000 | $200 | 12 | |
| 18 | 14 | Scott Pilgrim vs. the World | Uni. | $1,582,000 | -36.9% | 802 | -764 | $1,973 | $28,864,000 | $60 | 4 | |
| 19 | 17 | Get Low | SPC | $1,258,000 | -23.3% | 560 | -10 | $2,246 | $5,457,000 | $7 | 6 | |
| 20 | 15 | Salt | Sony | $1,250,000 | -33.6% | 705 | -463 | $1,773 | $115,211,000 | $110 | 7 | |